INBRE Students Study Exploring the Effects of Bacteria on Health
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INBRE Students Study the Effects of Bacteria on Health

Dr. Lori Koziol Explores the Effects of Bacteria on Health

“Biology is like a puzzle,” notes Dr. Lori Koziol, Assistant Professor of Biology. “I’ve always liked puzzles. No one knows the answers to the questions that I have proposed. As our research uncovers information, we start to put the puzzle pieces together. It’s a fascinating process!”

Specializing in microbiology, Dr. Koziol is currently studying a bacterium known as Actinomyces naeslundii, that thrives on surfaces in the mouth and is a member of a living community referred to as a biofilm. Although A. naeslundii is not generally thought to be harmful to humans, studies have shown that the bacteria are part of dental plaque and perhaps contribute to periodontal disease. Dr. Koziol’s research is aimed at determining how genes involved in disease get turned on and off.  Recent studies have shown a connection between poor oral health and cardiovascular disease. The questions posed by Dr. Koziol may have implications not only for dental diseases but for cardiovascular diseases as well.

Students in Dr. Koziol’s “Genetics” class have also been involved in the research on A. naeslundii. “I could have given them a ‘canned lab’ with a pre-determined outcome,” notes Dr. Koziol. “But science doesn’t work that way. By conducting research where the answers are not already known, students have to troubleshoot. That translates into a classroom environment with a direct correlation to real scientific inquiry.”

The equipment and materials used to conduct Dr. Koziol’s research are expensive. Through the INBRE grant, New England College will make substantial improvements to the College’s classroom and laboratory facilities allowing students to conduct more sophisticated research projects. “The enhanced facilities will have great appeal to students interested in the biomedical sciences or who are looking to pursue graduate programs in the sciences,” notes Dr. Koziol. Laboratory renovations, expected to be completed for the spring semester, include additional equipment, cabinets, and workspaces, some of which will meet ADA requirements.

Not only will the grant allow New England College to upgrade its science laboratories, student and faculty researchers will also have the opportunity to use facilities at Dartmouth College and the University of New Hampshire. Dr. Koziol has been working closely with Dr. George O’Toole, Associate Professor of Microbiology and Immunology at Dartmouth Medical School who specializes in the study of biofilms.

According to Dr. Koziol, the INBRE grant awarded by the National Institutes of Health seeks to encourage research that furthers the knowledge of public health and that has the potential to benefit society. As she observes, “The INBRE grant will go a long way in supporting research professionals to do work that is beyond the call of the classroom. It’s hard to get money if you don’t already have it. For investigators like us, the INBRE grant puts us in a better position to apply for additional grants in the future.”

For more information about the New Hampshire Network of Biomedical Research Excellence (NH-INBRE), please visit their website at